DEMATEL（decision making and evaluation laboratory）is a method which identifies and distinguishes influencing factors based on the evaluation of the correlation of influencing factors. In management reality, it is difficult to evaluate the correlation of influencing factors, which limits the application of DEMATEL method. Therefore, this study first uses structural equation modeling based on partial least squares （PLS） to get direct cor- relation matrix of influencing factors, uses the traditional DEMATEL method to analyze the influential factors, and the PLS-DEMATEL method is further put forward. Finally, this study uses the PLS-DEMATEL method for i- dentifying influencing factors of organizational agility from the perspective of information technology （IT）. According to the calculation results, IT strategies to enhance organizational agility are given, and the effective- ness of the PLS-DEMATEL method is also verified.