Prognostic value of D-dimer in acute pancreatitis:A systematic review and meta-analysis

AIM To investigate the prognostic value of D-dimer in patients with acute pancreatitis(AP).METHODS Medline,EMbase,Cochrane library,CBM,CNKI and other resources(from the date of their establishment to October 2017)were searched systematically.Eligible cohort studies on the predictive value of D-dimer in AP patients were collected.Quality assessment and data extraction were performed in those clinical trials in line with the inclusion criteria.Meta Disc software was applied to carry out meta-analysis.RESULTS Eight studies were included in the quantitative analysis.The pooled sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio with corresponding 95%CI for prediction of severity of AP were 0.80(0.74-0.80),0.75(0.72-0.79),3.17(2.74-3.66),and 0.30(0.23-0.38),respectively.The area under the receiver operating characteristic curve was 0.8345(diagnostic odds ratio=11.47;95%CI:8.06-16.33),albeit with no significant heterogeneity(Q=4.57,I2=0.0%,P>0.1).CONCLUSION D-dimer has the potential to serve as a prognostic marker on admission for differentiating disease severity of AP.