A way using closed homogeneous batch reactor（CHBR） model in CHEMKIN4. 1 software to simulate the humidified combustion of hydrogen-oxygen mixture was described. The influences of initial reaction temperature, reaction pressure and the addition amount of water vapor on combustion of hydrogen-oxygen mixture were analyzed based on detailed chemical kinetic mechanism of hydrogen the initial reaction temperature, reaction pressure and the of influences on the ignition delay time and the maximum combustion. Simulation results showed that factors such as addition amount of water vapor will exerte certain amounts temperature of hydrogen combustion, and the variation a- mount of water vapor has a more significant influence on the maximum temperature and flame propagation speed of hydrogen combustion. This provides useful guidance for further studies of the humidified combustion of hydrogen-oxygen mixture in the laboratory.