Efficacy and prognosis of three-dimensional intracavitary brachytherapy for locally advanced cervical cancer

Objective To observe the curative effect of three-dimensional intracavitary brachytherapy for locally advanced cervical cancer,and to preliminarily analyze the related factors affecting the prognosis.Methods Sixty-three cases of locally advanced cervical cancer were treated with EBRT plus three-dimensional intracavitary radiotherapy combined with concurrent or sequential chemotherapy.The dosage of pelvic external irradiation was 50 to 60 Gy,which was completed within 5 to 6 weeks.The three-dimensional intracavitary post-irradiation was added 1 to 2 times a week,5 to 7 Gy each time.The short-term efficacy,progression-free survival,overall survival,related factors affecting survival and toxic side effects were analyzed.Results CR was found in 21 cases,PR in 29 cases,SD or PD in 6 cases,and primary lesions were reduced or stable in 7 cases,but regional lymph node metastasis or distant metastasis were found.The objective remission rate(CR+PR)was 79.36%.The median survival time was 40.61 months,the one-year survival rate was 93.1%,the three-year survival rate was 82.2%,and the median PFS was 33.31 months.Except that tumor stage and HR-CTV radiation dose had effect on survival,the other factors had no effect on survival.The incidence of grade 2 to 3 acute toxicity was 11.1%.The incidence of late toxicity in grade 2 to 3 was 12.6%.Conclusion Three-dimensional intracavitary brachytherapy has a good effect in the treatment of locally advanced cervical cancer.In addition to clinical staging as an independent prognostic factor,there is a certain correlation between dose parameters and prognosis and toxicity.