Correlation between drug resistance rates of Escherichia coli and antibacterial use density in patients with hematological diseases

Objective: In order to provide a reference for clinical rational use of antibiotics, we analyzed the correlation between drug resistance rates of Escherichia coli and antibacterial use density(AUD) in hospitalized patients with hematological diseases. Methods: A retrospective method was used to the drug resistance rates of Escherichia coli and AUD of frequently-used antibacterial drugs for hospitalized patients from 2013 to 2017 in the Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences. The correlation between drug resistance rates and AUD was analyzed using Spearman correlation method. Results: AUD of carbapenems were positively correlated with resistance rates of Escherichia coli to various antibiotics(ceftazidime r=0.685, P<0.05;piperacillin-tazobactam r=0.697, P <0.05;meropenem r= 0.812, P< 0.01;imipenem r=0.716, P<0.05). AUD of tigecycline was positively correlated with resistance rates of Escherichia coli to imipenem(r=0.777, P<0.01). Whereas, AUD of fluoroquinolones were negatively correlated with resistance rates of Escherichia coli to cefepime(r=-0.869, P<0.01). Conclusion: There is a correlation between the resistance rates of Escherichia coli and AUD. It is recommended that medical institutions strengthen supervision of the rational use of carbapenems and tigecycline in order to control and delay the growth of drug-resistant bacteria.