Clinical outcomes analysis of infertile women with unicornuate uterus in IVF-ET

Objective : To explore the differences in laboratory results and clinical pregnancy outcomes following IVF/ICSI-ET treatment between infertile women with unicornuate uterus and normal uterus. Methods : The data of 13 IVF/ICSI-ET cycles with unicornuate uterus in the ART Department of Peking Union Medical College Hospital from July 2015 to November 2017 were retrospectively analyzed. 39 patients with normal uterus were individually matched from the same period time according to the age,BMI,the reason of infertility and stimulation protocol as control group. The basic characteristics,ovulation stimulation,embryo culture results and clinical outcomes of the two groups were compared. Results : There were no significant differences in the age,BMI,duration of infertility,basic sex hormones levels,endometrial thickness and sex hormones levels on trigger day,total doses of gonadotropin (Gn) used,number of oocytes retrieved,number of mature oocytes,rate of fertilization,rate of good quality embryos and number of blastocysts of two group( P >0.05). The average number of embryos transferred per cycle (1.78 vs. 1.94),implantation rate (18.8% vs. 38.2%),pregnancy rate (33.3% vs. 60.0%),miscarriage rate (0% vs. 4.8%),live birth rate (33.3% vs. 45.7%) and single birth Cesarean delivery rate (0% vs. 69.2%) in the unicornuate uterus group were lower than those in the control group,but there were no significant differences ( P >0.05). The birth weight (3 510 g vs. 3 294 g) and vaginal delivery rate (100% vs. 30.8%) of the unicornuate uterus group were higher than those in the control group,but the differences were not statistically significant ( P >0.05). Conclusions : Unicornuate uterus did not affect ovarian response to stimulation and laboratory outcomes. To some extent,there might be no significant difference in implantation rate,clinical pregnancy rate,miscarriage rate and live birth rate between IVF patients with unicornuate uterus and those with normal uterus.