Clinical Efficacy and Safety of Butylphthalide combined with Atorvastatin in Elderly Patients with Acute Cerebral Infarction

Objective: To observe the clinical efficacy and side effects of butylphthalide combined with atorvastatin in elderly patients with acute cerebral infarction. Methods: 84 elderly patients with acute cerebral infarction admitted to our department of neurology from January 2016 to January 2018 were randomly divided into control group and observation group (42 cases).Both groups were treated with standardized ischemic stroke.Based on this,the patients of control group were treated with atorvastatin. The patients in the observation group were treated with butylphthalide injection on the basis of the control group. The treatment period of the two groups was 2 weeks.The clinical treatment effect, serum C-reactive protein (CRP), Hematological parameters such as total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), neurological deficit score (NIHSS), motor function score (Fugl-Meyer), daily living ability score (ADL), and after administration adverse reactions. Results: The clinical treatment efficiency of the observation group was statistically significantly higher than that of the control group( P <0.05).After treatment,the serum CRP,TC and LDL-C levels in the observation group were statistically significantly lower than those in the control group( P <0.05);There was no stignificant difference in Fugl-Meyer score between the two groups( P >0.05).The NIHSS score of the observation group was statistically significantly lower than that of the control group,and the ADL score was statistically significantly higher than that of the control group( P <0.05);there was no significant difference in adverse drug reactions between the two groups ( P >0.05). Conclusion: The clinical treatment effect of butylphthalide combined with atorvastatin in the treatment of acute cerebral infarction in the elderly is effective. It can effectively improve the clinical symptoms of patients, promote the return of normal blood parameters, improve the quality of life of patients,and increase the adverse reactions.It is suitable for